REPTILE (with some textures)

REPTILE (with some textures), originally uploaded by - Carsten -.

"Oral treatment of nematodiasis in reptiles can be very challenging. especially in stressed. uncooperative or dangerous species. A combination of emodepside and praziquantel (Profender [R], Bayer) for topical application might he a better treatment option," researchers in Paris, France report.

"A pharmacokinetic study was performed with 12 healthy adult specimens from different reptile species with different types of skin. Blood was collected before treatment and at 3 intervals (5, 24 and 48 hours) after treatment with topical emodepside/praziquantel at a dosage of 0.56 ml per kg bodyweight (bw), corresponding to 12 mg emodepside and 48 in, praziquantel per kg bw. Serum from 20 Untreated specimens was collected and pooled as baseline data. The results showed that both actives penetrate reptile skin, as seen in the cat, and can be found in the serum in different levels depending oil the species, Reptiles with a thicker integument showed relatively low concentrations for both praziquantel and emodepside. In addition, a dose titration study was performed to establish an effective dose. depending oil the type and thickness of the integument," wrote L. Schilliger and colleagues.

The researchers concluded: "A dose of 4 drops per 100 g (1.12 ml per kg bw, 24 mg emodepside and 96 mg praziquantel per kg bw) was found to be effective in thick-skinned reptiles."

Schilliger and colleagues published their study in Revue de Medecine Veterinaire (Absorption and efficacy of a spot-on combination containing emodepside plus praziquantel in reptiles. Revue de Medecine Veterinaire, 2009;160(12):557-561).

For additional information, contact L. Schilliger, CVVA, 35 Rue Leconte de Lisle, F-75016 Paris, France.

Publisher contact information for the journal Revue de Medecine Veterinaire is: Ecole Nationale Veterinaire Toulouse, 23 Chemin Des Capelles, 31076

Toulouse Cedex 3, France.

Keywords: City:Paris, Country:France, Veterinary Research

This article was prepared by Veterinary Research Week editors from staff and other reports. Copyright 2010, Veterinary Research Week via VerticalNews.com.

Source Citation
"Reports summarize veterinary medicine study results from L. Schilliger and co-researchers." Veterinary Research Week 22 Mar. 2010: 6. General OneFile. Web. 8 Apr. 2010.
Document URL
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Disclaimer:This information is not a tool for self-diagnosis or a substitute for professional care.